Binary pan-cancer classes with distinct
WebJul 19, 2024 · Reference: Pearson JD, Huang K, Pacal M, et al. Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Cancer Cell. 2024. doi: 10.1016/j.ccell.2024.06.016 This article has been republished from the following materials. Note: material may have been edited for length and content. WebHere, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain- and loss-of-function studies across multiple murine and human tumor types, we show that opposite pro- or anti-cancer YAP activity functionally defines binary YAPon or YAPoff ...
Binary pan-cancer classes with distinct
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WebHere, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain- and loss-of-function studies across multiple murine and human tumor types, we show that opposite pro- or anti-cancer YAP activity functionally defines binary YAPon or YAPoff ... WebSep 24, 2024 · Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Article. Jul 2024; Joel D. Pearson; Katherine Huang; Marek Pacal; Rod Bremner;
WebJul 16, 2024 · The researchers hope by deducing common vulnerabilities of these types of cancer, it may be possible to develop new therapeutic approaches and improve patient outcomes. More information: Joel D.... WebBinary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. J. Pearson, Katherine Huang, +23 authors R. Bremner; Biology, Medicine. Cancer cell. 2024; 52. Save. Alert. YAP1 is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Pancreatic Cancer.
WebFigure 1. Features and mechanisms underlying binary YAP on and YAP off cancer superclasses. (a) Features of YAP/TAZ-deficient (YAP off) and YAP/TAZ-positive (YAP on) cancer classes, including the types, genetic and phenotypic characteristics, and key vulnerabilities.(b) Opposite anti- versus pro-oncogenic YAP/TEAD functions in YAP off … WebSep 24, 2024 · Features and mechanisms underlying binary YAP on and YAP off cancer superclasses. (a) Features of YAP/TAZ-deficient (YAP off) and YAP/TAZ-positive (YAP on) cancer classes, including the types, genetic and phenotypic characteristics, and key vulnerabilities.(b) Opposite anti- versus pro-oncogenic YAP/TEAD functions in YAP off …
WebMar 30, 2024 · Sorted in a descending order, distinct differences were found for the prevalence of different cancer types and histograms roughly show a power-law (long-tail) distribution trend. That is, a few cancer types at the head occupy the majority of the sample, while many categories at the tail occupy only a small portion of the total sample.
WebBinary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Cancer Cell, 39(8), 1115–1134.e12. doi:10.1016/j.ccell.2024.06.016 popularity of music genresWebJun 21, 2024 · The binary cancer groups exhibit distinct YAP-dependent adhesive behavior, and pharmaceutical vulnerabilities, underscoring clinical relevance. … popularity of name janeWebSep 24, 2024 · The YAP off class consisted of virtually all blood cancers (leukemia, lymphoma, and myeloma), many neural cancers (retinoblastoma, low-grade glioma, … popularity of name lillianWebMD, PhD. Pulmonary Pathologist, Division of Pathology & Laboratory Medicine. Director, Pathology Research Core. Professor, UC Department of Pathology and Laboratory Medicine. [email protected]. Board Certified. Kathryn A. Wikenheiser-Brokamp, MD, PhD About Education and Training Publications Patient … popularity of monarchy ukWebSep 22, 2024 · The binary cancer groups exhibit distinct YAP-dependent adhesive behavior and pharmaceutical vulnerabilities, underscoring clinical relevance. … popularity of name janetWebNational Center for Biotechnology Information popularity of name marigoldWebJul 15, 2024 · Here, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. … shark jumping on boat