Cisplatin hepatotoxicity

Author: belh

August undefined, 2024

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … WebApr 13, 2024 · Conclusions: This study elucidated the mechanism by which gut microbiota mediates cisplatin hepatotoxicity through enhanced inflammatory response and …

Molecular mechanisms of cisplatin-induced nephrotoxicity: a …

WebAn association between cisplatin administration and hepatotoxicity is proposed in this patient. Conclusions: This patient may have experienced cisplatin-induced liver … WebMultivariate analysis showed that HIPEC regimen was the main risk factor of hepatotoxicity induced by HIPEC, with cisplatin + docetaxel being an independent risk factor of the HIPEC-induced hepatotoxicity. Open HIPEC techniques and HIPEC duration more than 60 minutes tend to increase the incidence of hepatotoxicity. binary file to txt

Applied Sciences Free Full-Text Ginkgo biloba Alleviates Cisplatin ...

WebMay 18, 2024 · Cisplatin is an anti-neoplastic agent for solid organ tumors has side effects on most organs including hepatotoxicity. 21, 22 In this study, we showed that CP can significantly induce hepatotoxicity in … WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). WebCisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin mediates its tumorcidal effects via a number of different cytotoxic mechanisms. Although it is best known for DNA damage, … binary file viewer free

Alleviation of cisplatin‐induced hepatotoxicity by …

Cisplatin hepatotoxicity

Ethanol extract of Crataeva nurvala stem bark reverses cisplatin ...

WebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum … WebJan 14, 2024 · This study was designed to investigate the protective effects of Centella asiatica (CA) on cisplatin-induced hepatotoxicity and to clarify the underlying …

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WebFeb 1, 2024 · Hesperidin plays an important role in the prevention of many diseases due to its anti-inflammatory, anti-oxidant, anti-ulcer, and anti-carcinogenic activities,2,3in addition to its anti-melanogenic and neuroprotective effects.4,5Moreover, it has anti-microbial, anti-allergic, immunomodulatory, hepatoprotective, and nephroprotective effects.6-8The … WebPreventive Effect of Curcumin against Cisplatin-related Hepatotoxicity in Swiss Albino mice (Mus musculus L.) Jul 2024 - Jun 2024 …

WebSep 15, 2024 · Cisplatin is mutagenic, teratogenic and carcinogenic and its use has been show to increase the risk of secondary malignancies, particularly leukemia. … Webabstract = "Generation of free radicals in the kidney cortex plays an important role in the pathogenesis of cisplatin-induced dysfunction of renal proximal tubule cells.

WebThe results suggest that the plant extract (250 and 500 mg/kg) was effective in significantly altering the indices of cisplatin induced dysfunction of renal proximal tubule cells under oxidative stress by decreasing the concentration of … WebApr 1, 1993 · To report a case of possible cisplatin-associated hepatotoxicity. CASE SUMMARY: A 69-year-old man received three cycles of cisplatin (100 mg/m 2 ) and …

WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP.

WebSynergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity. … cypress io iconWebNational Center for Biotechnology Information cypress.io pluginsWebTo date, no published guidelines exist for managing a cisplatin overdose. The major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, … cypress isd pay scaleWebHepatotoxicity was induced in animals by an intraperitoneal injec-tion of acetaminophen (750 mg/kg body weight) in a freshly prepared physi-ological saline solution kept in warm boiling water bath and used after cooling at 370C, as a single dose on the first day. The rats were randomly divided into five groups of six animals each as given below. cypress irelandWebFeb 2, 2024 · There is substantial evidence that protective medications can alleviate drug-induced organ toxicity by modulating both Nrf2 and NF-κB signaling pathways. Thus, it has become increasingly important to explore the crosstalk mechanism between Nrf2 and NF-κB in drug-induced toxicity. binary fill holesWebOne of greatest key mechanisms of Cis toxicity is the induction of oxidative stress. Under normal conditions, ROS are controlled by cells through harmonizing the production of ROS with their removal by scavenging system. Oxidative stress results in extreme damage of cellular proteins, lipids and DNA, leading to critical cellular injuries. cypress.io incWebDrug-induced liver injury (DILI) is the most common cause of acute liver failure worldwide. 1, 2 Cisplatin (CP) is one of the most common and potent anti-neoplastic agents used against testicular, ovarian, cervical, as well as bladder malignancies. 3 – 6 Despite its effectiveness, CP use is limited due to its serious toxic side effects such as … cypress isk