WebDec 16, 2024 · Cisplatin (CDDP; cis-dichlorodiammine platinum [II]) is a non-specific drug of the cell cycle with strong cytotoxicity and broad-spectrum antitumor effects; it is widely used in urogenital system tumors, malignant lymphoma, breast cancer, head and neck cancer, non-small cell lung cancer, etc. ( 1 – 3) Cisplatin-induced nephrotoxicity is … WebSep 8, 2024 · Cisplatin is an antineoplastic agent widely used, and no effective treatments capable of preventing cisplatin-induced ototoxicity and neurotoxicity in humans have yet been identified.
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WebMay 31, 2024 · Clinical manifestations include nausea, vomiting, abdominal pain, diarrhea, weight loss, malnutrition, and bleeding (usually in patients with colonic involvement). This topic review will focus on the diagnosis and management of chronic radiation injury to the small intestine and proximal colon. WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent necroptosis in cisplatin-induced ototoxicity in vitro and in vivo. Sprague–Dawley rats (SD, 8 … how much sand for 20 ft round pool
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WebAbstract. Cisplatin (CP) is an effective chemotherapeutic agent used in the treatment of a variety of solid tumours. The most frequently observed side-effect of the use of CP is … WebDec 5, 2024 · Cisplatin is an antineoplastic agent, used in the treatment of different types of malignant neoplasms. Side effects such as ototoxicity, nephrotoxicity, and bone marrow toxicity are the main limitations of its clinical use. WebKidney disease is one of the most common diseases in humans. Common types of kidney disease include acute kidney injury (AKI), renal fibrosis, polycystic kidney disease, and … how do scientist use models