WebIncreasing evidence emphasizes the notion that CTGF is pivotal in cancer initiation and progression. The interplay of tumor cells and the tumor microenvironment significantly … WebCCN (for CYR61/ CTGF /NOV) proteins were identified originally from diverse cellular contexts and studied for their growth-promoting activities. It is now known that there are …
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WebSep 9, 2015 · High expression of CTGF in breast tumor epithelial component correlates with poor clinical prognosis and outcomes. The interaction between tumor and stromal cells and their signaling output mould the microenvironment to support tumorigenesis and metastasis [].In this context, cytokines, chemokines, as well as growth, angiogenesis and … WebOf late, there is accumulating evidence that CTGF expression is highly correlated with the development of cancers. 5 Elevated CTGF expression has been observed in mammary …
WebApr 7, 2024 · Recently, CTGF was also found to play an important role in the growth of bone metastases from prostate and breast cancer through forming CTGF–Runx2–RANKL axis 37. WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast …
WebJul 8, 2013 · Accordingly, we investigated the function of connective tissue growth factor (CTGF), a protein known to be important in stromal formation. CTGF is a pleiotropic and cysteine-rich matricellular protein that is abundant in many solid malignancies including pancreas, breast, esophageal, glioblastoma, and hepatocellular carcinoma ( 18 – 23 ). WebSep 12, 2024 · INTRODUCTION. Urothelial bladder cancer (UBC) is a common urinary malignancy. In 2012, about 429,800 new cases and 165,100 deaths arising from UBC occur worldwide [].In the United States, UBC is estimated that to be the second most frequent genitourinary tract cancer and the fourth most common cancer in male in 2024 [].At …
WebMar 3, 2004 · Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells, but few mechanistic details are known. We investigated the roles of CTGF and collapsin response mediator protein 1 (CRMP-1) in metastasis and invasion of human lung adenocarcinoma.
WebMay 10, 2024 · Our findings suggest that CTGF is a marker for medulloblastoma independent of molecular subgroups and its transcriptional program is active at the … flip phones at amazonWebJul 18, 2024 · Dynamic interaction between prostate cancer and the bone microenvironment is a major contributor to metastasis of prostate cancer to bone. In this study, we utilized an in vitro co-culture model of PC3 prostate cancer cells and osteoblasts followed by microarray based gene expression profiling to identify previously unrecognized prostate … greatest polish kingWebMar 10, 2024 · CTGF is overexpressed in triple-negative breast cancer. In a publicly available gene expression database, the Cancer Cell Line Encyclopedia portal, we … greatest polish leadersWebConnective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis. greatest polka albums of all timeWebApr 20, 2024 · a The efficacies of the first-line anti-cancer drugs (Cisplatin and 5-FU) were assessed on GC cells after knocking down AMOTL1, YAP1, CTGF, and control, respectively. b The IC 50 of VP was ... greatest political philosophersWebMar 21, 2024 · These eight phenotypes are “TNF- CTGF- GLUT4+”, “TNF- CTGF+ GLUT4-”, “TNF- CTGF+ GLUT4+”, “TNF+ CTGF- GLUT4-”, “TNF+ CTGF- GLUT4+”, “TNF+ CTGF+ GLUT4-”, ... M2 and tumor-associated macrophages (TAMs) type M1 (M1-TAM) and type M2 (M2-TAM) (Figure 1E). Using this computational approach, we found that insulin … greatest political leaders of all timeWebConnective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. ... CCN2 inhibits lung cancer … flip phones at rogers