Cytofectins
WebMar 9, 2011 · Cytotoxins. Cytotoxins are the chemical weapons that Killer T-cells use to destroy infected cells. Viruses take over healthy cells and trick them into making many … WebCationic lipids (cytofectins) have gained widespread acceptance as pharmaceutical polynucleotide delivery agents for both cultured cell and in vivo transfection, and the cytofectins DOTAP and...
Cytofectins
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WebThis invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this inventio WebBoth single-stranded and double-stranded DNAs were active in the presence of cytofectins. Macrophage activation by the DNA-cytofectin complexes was reduced by chloroquine, …
WebNov 1, 2005 · Novel N,N‘-diacyl-1,2-diaminopropyl-3-carbamoyl[bis-(2-dimethylaminoethane)] bivalent cationic lipids were synthesized and evaluated for in … WebNational Center for Biotechnology Information
WebPromising advances in nonviral gene transfer have been made as a result of the production of cationic liposomes formulated with synthetic cationic lipids (cytofectins) that are able to transfect cells. However few cationic liposome systems have been examined for their ability to transfect CNS cells. Websystems, including cytofectins, can substantially increase the delivery of antisense compounds to cells, as well as the con-sequent pharmacological effects (6,7). Thus it is …
WebA large number of liposome-based non-viral gene and siRNA delivery systems include monovalent cholesteryl cytofectins with acyclic head groups in their formulations. Progress in their clinical development has, however, been hampered by relatively low transfection efficiencies.
WebApr 4, 2002 · Both of these cytofectins are predicted to produce relatively fluid bilayer liposome structures due to the short alkyl side chain of GAP-DLRIE (C12:0) and the mono-unsaturated C14 side chain of GAP-DMORIE (C14:1). In addition, the co-lipid used in the lipoplex formulations is also important, and thus structural differences in either or both ... cincinnati to rochester flightsWebSep 28, 2008 · Download Citation Cationic Lipid/Polynucleotide Condensates for in Vitro and in Vivo Polynucleotide Delivery - the Cytofectins Abstract Cationic liposomes have … dhule famous forWebproduce cytofectins which afford liposomes with high transfection potential, the nature of the linkage, spacer length and cationic head group have been examined (Figure 1). Thus, it has been shown that the ether linkage between the hydrophobic cholesteryl skeleton and the spacer affords compounds which lead to higher transfection ... cincinnati to rhode islandWebFeb 1, 2008 · Two novel cholesterol-based cytofectins containing primary amino head groups, glycylcholesteryl formylhydrazide (MS10) and beta-alanylcholesterylformylhydrazide (MS11), have been prepared and incorporated into unilamellar cationic liposomes in equimolar amounts with dioleoylphosphatidylethanolamine (DOPE) as colipid. cincinnati to seattle flight timeWebcytofectins transfective derivatized Prior art date 1996-04-09 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Granted Application number CA002251169A Other languages French (fr) Other versions ... cincinnati to sheboyganWebCompositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing mic cincinnati to shelbyville kyWebFeb 1, 1996 · Cationic lipids (cytofectins) have gained widespread acceptance as pharmaceutical polynucleotide delivery agents for both cultured cell and in vivo transfection, and the cytofectins DOTAP and DC-Cholesterol are being tested in clinical human gene therapy trials. This study reports the effects of modifications in the hydrophobic domain … cincinnati to shanghai