Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell. Dynamin is part of the "dynamin superfamily", which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA1, mitofusins, and GBPs. Members of the dynamin family are principally involved in the scission of newly formed vesicles … See more Dynamin itself is a 96 kDa enzyme, and was first isolated when researchers were attempting to isolate new microtubule-based motors from the bovine brain. Dynamin has been extensively studied in the context of See more During clathrin-mediated endocytosis, the cell membrane invaginates to form a budding vesicle. Dynamin binds to and assembles around the neck of the endocytic vesicle, … See more Small molecule inhibitors of dynamin activity have been developed, including Dynasore and photoswitchable derivatives (Dynazo) for spatiotemporal control of endocytosis with light (photopharmacology). See more • Dynamins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more In mammals, three different dynamin genes have been identified with key sequence differences in their Pleckstrin homology domains … See more Mutations in Dynamin II have been found to cause dominant intermediate Charcot-Marie-Tooth disease. Epileptic encephalopathy–causing de novo mutations in dynamin have been suggested to cause dysfunction of vesicle scission during … See more WebJan 11, 2012 · Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role …
Dynamin, a membrane-remodelling GTPase - Nature
WebOct 26, 2024 · Guanylate-binding proteins (GBPs) were originally identified as proteins induced by IFN-γ in human fibroblasts. 1 These proteins belong to the superfamily of large GTPases related to dynamin and ... WebJul 7, 2024 · National Center for Biotechnology Information cshp radiology medical center point
Dynamin-2 deficiency causes age- and sex-dependent …
WebOct 13, 2024 · A novel member of the dynamin family of GTP-binding proteins is expressed specifically in the testis.. J. Cell Sci. 105, 1-5. Medline, Google Scholar; 30 Oh P., McIntosh D.P., Schnitzer J.E. (1998). Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium.. J. WebVitellogenesis, the timely production and uptake of yolk proteins, is essential for female fecundity. In the silkworm, Bombyx mori, a nucleus‐enriched long‐noncoding RNA (lncRNA) lncR26319 regulates Endophilin A (EndoA), a member of the endophilin protein family of endocytosis, by competitively binding to miR‐2834.The lncR26319‐miR‐2834‐EndoA axis … WebAug 1, 2001 · Dynamin family members are involved in numerous cellular processes. This schematic diagram illustrates the location of dynamin-like proteins within animal and yeast cells (left) and within plant cells (right). Below is a table corresponding to the diagram which indicates the location, function and self-assembly properties of the dynamin family ... cshp residency programs