WebIron storage proteins, ferritin (Ftn) and bacterioferritin (Bfr), are dynamic regulators of iron levels in bacteria. Ftn and Bfr appear to be essential for the survival and virulence of … WebIron storage proteins, ferritin (Ftn) and bacterioferritin (Bfr), are dynamic regulators of iron levels in bacteria. Ftn and Bfr appear to be essential for the survival and virulence of pathogens in a host, suggesting that these molecules may be good targets for the development of new antibiotics.
Differential Roles of Iron Storage Proteins in Maintaining the …
WebOct 25, 2005 · Iron-storage protein, whose ferroxidase center binds Fe 2+ ions, oxidizes them by dioxygen to Fe 3+, and participates in the subsequent Fe 3+ oxide mineral core formation within the central cavity of the protein complex. The mineralized iron core can contain as many as 2700 iron atoms/24-meric molecule. 2 publications Miscellaneous WebMar 26, 2002 · bfr is the second gene in an operon and is preceded by bfd, a gene that encodes a 64-aa protein with a [2Fe-2S] site; it may act as a regulatory component for the … may the lord watch between me and thee verse
Bacterioferritin: a key iron storage modulator that affects strain ...
WebJan 6, 2024 · Our data suggests that BfrA is required for efficient utilization of stored iron under low iron conditions while BfrB plays a crucial role as the major defense protein … WebAug 14, 2024 · Effects of bfr mutation on strain growth and iron storage capacity. a Comparison of the growth of the wild-type and mutant strains in SFM with 100 μM Fe. b SEM observations of the morphological ... WebApr 1, 2015 · The iron storage protein bacterioferritin (Bfr) has the unique property of binding 12 heme groups in its protein shell. We substituted the hemes with the well-known photosensitizer, zinc protoporphryin IX and loaded the inner cavity of Bfr with ~1000 irons as a ferric oxyhydroxide polymer. We also fused the RGD4C tumor-targeting peptide to the ... may the lord send angels lyrics