Phospho irf1
Another transcription factor of the IRF family important for antiviral defenses [6, 18], IRF1, has previously also been implicated with the DNA damage response [26]. We hypothesized that upon genotoxic insult, IRF1 might be a downstream target of the RLR/IRF3 pathway, as reported for virus infection [18], and thereby … See more To investigate the molecular links between DNA damage-induced cell death and innate immune signaling, we used A549 human lung carcinoma cells, as they … See more In order to investigate the contribution of antiviral signaling cascades to the induction of DSB-induced cell death, we compared the impact of the major antiviral … See more Above we have shown that RLR/IRF3 signaling as well as expression of IRF1 are important for DNA damage-induced cell death. Furthermore, across all conditions … See more
Phospho irf1
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WebJan 21, 2024 · The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader view, linking IRF1 to a wide range of ... WebIRF-1 is serine-phosphorylated by casein kinase II (CKII) at two clustered sites, one in the DNA-binding domain (amino acids 138-150) and another in the transactivation domain …
WebNov 27, 2024 · Optic atrophy 1 (OPA1) controls IM fusion and protects cells with mitochondrial dysfunction due to Mfn1 deficiencies 9, 10, 11. Two OM proteins, named FAM73a (also known as mitoguardin 1) and... WebWe hypothesize that our methodology will enable the efficient identification of IRF-specific and pan-IRF inhibitors that can be used for the treatment of IRF-dependent disorders and malignancies. Introduction In 1988 the first interferon regulatory factor (IRF) was identified and named IRF1 ( 1, 2 ).
WebIRF1-knockout HeLa cells were generated using the clustered, regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system, which was performed by ToolGen (Seoul, South Korea). The sequence of single-guide (sg)RNA used to target the human IRF1 gene was CTCGGATGCGCATGAGACCC TGG. WebApr 16, 2002 · Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor …
WebMar 11, 2024 · Abstract and Figures. IRF1 (Interferon Regulatory Factor-1) is the prototype of the IRF family of DNA binding transcription factors. IRF1 protein expression is …
Web(C) GST–IRF-1 (100 ng) was immobilized on a microtitre plate and incubated with a titration (0–100 ng) of MDM2. Protein binding was detected using an anti-MDM2 mAb and the … how big of a file can you upload on gmailWebGet better batch-to-batch reproducibility with a recombinant antibody. Anti-IRE1 (phospho S724) antibody [EPR5253] (ab124945) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast production. how many ounces of liquor per drinkWeb0.1ml Phospho-EphA2(Tyr594) 磷酸化酪氨酸蛋白激酶A2受体抗体 96T/48T 0.2ml EphA4 R/Eph receptor A4 酪氨酸蛋白激酶A4受体抗体 96T/48T 0.1ml EphB2 R 酪氨酸蛋白激酶受体B2抗体 96T/48T how big of a file is the epic games launcherWeb2 days ago · (B) Total protein extracts from peritoneal macrophages (1 × 10 6) stimulated with LPS for 30 min were analyzed by Western blot using specific anti-phospho–NF–κB p65 (Ser536), anti-IκB-α (L35A5) and anti-β-actin antibodies. (C) Anti-phospho–NF–κB p65 and anti-IκB-α (L35A5) quantification by densitometry, after normalization with ... how many ounces of miralax before colonoscopyWebPhospho-IRF7 (Ser437/438) IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to ... how many ounces of loose leaf tea per cupWebMay 13, 2024 · IRF-1 Antibody (E-4) is a mouse monoclonal IgG 2a κ IRF-1 antibody, cited in 19 publications, provided at 200 µg/ml specific for an epitope mapping between amino acids 307-328 at the C-terminus of IRF-1 of mouse origin IRF-1 Antibody (E-4) is recommended for detection of IRF-1 of mouse, rat and human origin by WB, IP, IF and ELISA how many ounces of milk for 4 month oldWebNational Center for Biotechnology Information how big of a file can you email in hotmail